Searcy is located within 10 hours from several major U.S. cities, including:
| Little Rock | 52 miles | 50 minutes |
| Memphis | 105 miles | 2 hours |
| St. Louis | 296 miles | 5.5 hours |
| Nashville | 317 miles | 5.5 hours |
| Oklahoma City | 357 miles | 5.5 hours |
| Dallas | 367 miles | 5.5 hours |
| Kansas City | 445 miles | 7 hours |
| Houston | 488 miles | 8 hours |
| Atlanta | 492 miles | 9 hours |
| Louisville | 493 miles | 8 hours |
| Knoxville | 497 miles | 8 hours |
| New Orleans | 500 miles | 8 hours |
| Cincinnati | 598 miles | 10 hours |
From I-40 E (Oklahoma City & Kansas City): Follow US 64 E (Exit 127) to US 67 N. Take Exit 45 to Beebe Capps. Turn left. Follow Beebe Capps to Harding University. Turn right onto Burks Blvd.
From I-40 W/I-55 N (Memphis, Nashville, Atlanta, New Orleans): Follow US 64 W to Bald Knob. Turn left onto US 67 S. Take Exit 45 to Beebe Capps. Turn right. Follow Beebe Capps to Harding University. Turn right onto Burks Blvd.
From I-30 E (Dallas): Follow US 67 N to Exit 45-Beebe Capps. Turn left. Follow Beebe Capps to Harding University. Turn right onto Burks Blvd.
From US 67 S (St. Louis): Take Exit 45-Beebe Capps. Turn right. Follow Beebe Capps to Harding University. Turn right onto Burks Blvd.
From US 67 N (Little Rock): Take Exit 45-Beebe Capps. Turn left. Follow Beebe Capps to Harding University. Turn right onto Burks Blvd.
